Features of the use of the drug "Buserelin-depot"

Features of the use of the drug "Buserelin-depot"
Features of the use of the drug "Buserelin-depot"
Anonim

Pharmacological action of the drug

buserelin depot and pregnancy
buserelin depot and pregnancy

Means "Buserelin-depot" is an anticancer drug, which is a synthetic analogue of GnRH. As a result of the use of this drug, there is a suppression of the production of sex hormones in the gonads, which ultimately leads to a decrease in testosterone levels in men and estradiol (to postmenopausal values) in women. The basis of the action of the drug "Buserelin-depot" is competitive binding to receptors located in the anterior pituitary gland, and stimulating a short-term increase in the amount of steroid biologically active substances in plasma. As for the pharmacokinetics of this drug, on average, after twelve to fourteen days of constant use, a complete blockade of the gonadotropic function occurs.

buserelin depot
buserelin depot

Description of release form and composition

The drug "Buserelin-depot" is produced in the form of a lyophilizate intended for the preparation of a suspension. It comes with a special solvent, which is a clear, colorless liquid. The composition of this tool as an active ingredient includes 3.75 milligrams of buserelin acetate. Additional ingredients are D-mannitol, polysorbate 80, D, L-lactic acid copolymer, glycolic acid copolymer and sodium carboxymethylcellulose.

Medical indications for prescription

The Buserelin-Depot medicine is used, as a rule, for the treatment of patients with hormone-dependent pathology of the reproductive system, provoked by relative or absolute hyperestrogenism. For example, this drug is actively used for the treatment of uterine fibroids and endometriosis. Breast cancer in patients with a preserved menstrual cycle is also included in the list of indications for prescription. In addition, it is recommended to use this tool to induce ovulation during infertility treatment in so-called in vitro fertilization programs. And finally, the list of indications for use includes the therapy of hormone-dependent prostate cancer of the third and fourth stages.

buserelin depot and alcohol
buserelin depot and alcohol

Contraindications for taking

The use of this drug is strictly not recommended for patients who are breastfeeding. Also, the drug "Buserelin-depot" and pregnancy are absolutely incompatible. In addition, it should not be used by people suffering from hypersensitivity to any of its components. Buserelin-depot and alcohol are strictly incompatible.

Possible side effects

The use of this drug in some patients may cause flushing of the skin, urticaria and angioedema. In addition, women may experience adverse reactions such as sleep disturbance, headache, decreased libido, increased sweating, frequent mood changes, depression, vaginal dryness, hot flashes, menstrual bleeding and bone demineralization. In male patients, there is an increase in the concentration of androgens, gynecomastia, urinary retention, lymphostasis, renal edema and ossalgia.

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